NCSU



Todd R. Klaenhammer
Publications

Pfeiler, E. and T.R. Klaenhammer. 2009. Role of transporter proteins in bile tolerance of Lactobacillus acidophilus. Appl. Environ. Microbiol. 75:6013-6016.

O'Flaherty, S. and T.R. Klaenhammer. 2009. The role and potential of probiotic bacteria in the gut, and the communication between gut microflora and gut/host. International Dairy Journal, Online 2 December 2009.

Goh, Y.J. M. Andrea Azcárate-Peril, Sarah O’Flaherty, Evelyn Durmaz, Florence Valence, Daniel Mollé, Sylvie Lortal, and Todd R. Klaenhammer. 2009. Development of a upp-based Counterselective Gene Replacement System for Study of the S-layer protein SlpX in Lactobacillus acidophilus NCFM.  Appl. Environ. Microbiol. 75:3093-3105.

O’Flaherty, S., Y. J. Goh and T. R. Klaenhammer. 2009. Genomics of Probiotic Bacteria. Book chapter in press for the book Prebiotics and Probiotics Science and Technology published by Springer. 

Schroeter, J. and T.R. Klaenhammer.  Genomics of Lactic Acid Bacteria – Mini Review.  2009.  FEMS Microbiology Letters 292: 1-6.

Buck, B.L., A.Azcarate-Peril, and T.R. Klaenhammer. 2009.  Role of autoinducer-2 on the adhesion ability of Lactobacillus acidophilus.  J. Appl. Microbiology. J Appl. Microbiol. 2009 Mar 13. [Epub ahead of print] PMID: 19302300

Andrea Azcarate-Peril, M., Richard Tallon and Todd R. Klaenhammer. 2009. Temporal gene expression and probiotic attributes of Lactobacillus acidophilus during growth in milk.  J.Dairy Science 92: 870-886.

   Mohamadzadeh, M. and T.R. Klaenhammer.  2008.  Specific Lactobacillus species Differentially activate tol-like receptors and downstream signals in dendritic cells. Expert Reviews. 7:61-71. 

Mohamadzadeh, M., T. Duong, S. J. Sandwick, T. Hoover and T. R. Klaenhammer.  2009. Dendritic cell targeting of Bacillus anthracis protective antigen expressed by Lactobacillus acidophilus protects mice from lethal challenge.  Proc. Nat. Acad. Sci. USA.

Ventura, M., S. O’Flaherty, M.J. Claesson, F. Turroni, T.R. Klaenhammer, D. van Sinderen and P.W. O’Toole.  2009.  Genome-scale analyes of health-promoting bacteria:  probiogenomics.  Nat. Rev. Microbiol. 7:61-71.

Sergey R. Konstantinov, Hauke Smidt, Willem M. de Vos, Sven C.M. Bruijns, Satwinder Kaur Singh, Florence Valence, Daniel Molle, Sylvie Lortal, Eric Altermann, Todd R. Klaenhammer and Yvette van Kooyk   2008. S layer protein A of Lactobacillus acidophilus NCFM regulates immature dendritic cells and T-cells functions.  PNAS 105:19474-19479.

Goh, Y. J., and T.R. Klaenhammer. 2008.  Genomic features of Lactobacillus species    Frontiers of Bioscience 14: 1362-1386.

Callanan, Michael J and Klaenhammer, Todd R (September 2008) Bacteriophages in Industry. In: ENCYCLOPEDIA OF LIFE SCIENCES. John Wiley & Sons, Ltd: Chichester http://www.els.net/ [DOI: 10.1002/9780470015902.a0000776.pub2]

Azcarate-Peril MA, Altermann E, Goh YJ, Tallon R, Sanozky-Dawes RB, Pfeiler EA, O’Flaherty S, Buck BL, Dobson A, Duong T, Miller MJ, Barrangou R, Klaenhammer TR.  2008.  Analysis of the genome sequence of Lactobacillus gasseri ATCC 33323 reveals the molecular basis of an autochthonous intestinal          organism.  Appl Environ Microbiol. 74:4610-4625.      

Mohamadzadeh, M., T. Duong, T. Hoover, and T.R. Klaenhammer. 2008. Targeting mucosal dendritic cells with microbial antigens from probiotic lactic acid bacteria.  Expert Reviews Vaccines.  7:163-174.

Durmaz. E., Miller, M.J., Azcarate-Peril, M. A., Toon, S. P. and T. R. Klaenhammer. 2008. Genome sequence and characteristics of Lrm1, a prophage from industrial Lactobacillus rhamnosus strain M1.  Appl. Environ. Microbiol.  74:4601- 4609.

Duong, T. and T.R. Klaenhammer.  2008.  Functional genomics of lactic acid bacteria.  In, Therapeutic Microbiology: Probiotics and Other Strategies. J. Versalovic and M. Wilson, Eds.  Pp 193-204. ASM Press, Washington, DC. 

Carroll IM, Andrus JM, Bruno-Barcena JM, Klaenhammer TR, Hassan HM,Threadgill DS.  2007.  The Anti-inflammatory Properties of Lactobacillus gasseri Expressing Manganese Superoxide Dismutase (MnSOD) Using the Interleukin 10-Deficient Mouse Model of Colitis. Am J Physiol Gastrointest Liver Physiol. 293:G729-38.

Klaenhammer, T.R., E. Altermann, E. Pfeiler, B.L. Buck, T. Duong, Y.J. Goh, R. Tallon, S. O’Flaherty, R. Barrangou, and M.A. Azcarate-Peril. 2008. Functional Genomics of Probiotic Lactobacilli. J. Clinical Gastroenterology.  In Press.

Sturino, J.M. and T.R. Klaenhammer. 2007.  Inhibition of bacteriophage replication in Streptococcus thermophilus by subunity poisoning of primase.  Microbiology 153:3295-3302.

Pfeiler, E.A., and T.R. Klaenhammer. 2007.  The genomics of lactic acid bacteria. Trends in Microbiology.  15:546-553.

Klaenhammer, T.R., M. Andrea. Azcarate-Peril, E. Altermann, and R. Barrangou. 2007.  Influence of the dairy environment on gene expression and substrate utilization in lactic acid bacteria.  J. Nutrition. 137(3):748S-750S.  

Durmaz, E. and T.R. Klaenhammer.  2007.  Abortive phage resistance mechanism AbiZ speeds the lysis clock to cause premature lysis of phage infected Lactococcus Lacts.  J. Bacteriol.  189:1417-1425.

Klaenhammer, T.R. Probiotics and Prebiotics. 2007.  In Doyle, Beuchat, and Montville (eds.).  Food Microbiology: Fundamentals and Frontiers, 3rd edition.  ASM Press, Washington, DC, pp 891-907.

Klaenhammer, T.R., Pfeiler, E. and Duong, T.  2007.  Genomics and Proteomics of Food-Borne Microorganisms.  In Doyle, Beuchat, and Montville (eds.).  Food Microbiology: Fundamentals and Frontiers, 3rd edition.  ASM Press, Washington, DC, pp 935-951.

Dobson, A.E., R.B. Sanozky-Dawes, and T.R. Klaenhammer. 2007. Identification of an operon and inducing peptide involved in the production of lactacin B by Lactobacillus acidophilus. J Appl Microbiol.  103:1766-78.

Callanan, M.J., W.M. Russell, T. R. Klaenhammer.  2007. Modification of Lactobacillus b-glucuronidase activity by random mutagenesis.  Gene 389:122-127.

Pfeiler, E.A., M. A. Azcarate-Peril, and T. R. Klaenhammer. 2007. Characterization of a two component regulatory system implicated in the bile tolerance of Lactobacillus acidophilus NCFM.  J. Bacteriol. 189:4624-4634. 

            
Azcarate-Peril, M.A., J.M. Bruno-Barcena, H.M. Hassan and T.R. Klaenhammer. 2006. Transcriptional and functional analysis of oxalyl-coenzyme A (CoA) decarboxylase and formyl-CoA transferase genes from Lactobacillus acidophilus. Appl. Environ. Microbiol. 72:1891-1899.

Barrangou, R., M.A. Azcarate-Peril, T. Duong, S.B. Conners, R.M. Kelly, and T.R. Klaenhammer. 2006. Global analysis of carbohydrate utilization by Lactobacillus acidophilus using cDNA microarrays. Proc. Nat. Acad. Sci. USA 103: 3816-3821.

Sturino, J., and T.R. Klaenhammer. 2006. Engineered bacteriophage defenses systems in bioprocessing. Nature Reviews 4:395-404.

Klaenhammer, T.R., E. Pfeiler, and T. Duong. 2006. Genomics and proteomics of food-borne microorganisms. In Doyle, Beuchat, and Montville (eds.). Food Microbiology: Fundamentals and Frontiers, 3rd edition. ASM Press, Washington, DC. In Press.

Altermann, E., W. M. Russell, M.A.Azcarate-Peril, R. Barrangou, B.L.Buck, O. McAuliffe, N. Souther, A. Dobsen, T. Doung, M. Callanan, S. Lick, A. Hamrick, R. Cano, and T.R. Klaenhammer. 2005. Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM. Proc. Nat. Acad. Sci. USA 102:3906-3912.

Mohamadzadeh, M., S. Olson, W.V. Kalina, G. Ruthel, G.L. Demmin, K.L. Warfield, S.Bavari, and T. R. Klaenhammer. 2005. Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization. Proc. Nat. Acad. Sci. USA 102:2280-2285.

Rastall, R.A., G.R. Gibson, H.S. Gill, F. Guarner, T. R. Klaenhammer, B. Pot, G. Reid, I.R. Rowland, M.E. Sanders. 2005. Modulation of the microbial ecology of the human colon by probiotics, prebiotics and synbiotics to enhance human health: An overview of enabling science and potential applications. FEMS Microbiology Ecology 52:145-152.

Bruno-Barcena, J.M., M.A. Azcarate-Peril, T.R. Klaenhammer, and H.M. Hassan. 2005. Marker-free chromosoaml integartion of the managanese superoxide dismutase gene (sodA) from Streptococcus thermophilus into Lactobacillus gasseri. FEMS Microbiology Letters 246:91-101.

Lu, Z., E.Altermann, F.Breidt, P. Predki, H.P. Fleming and T.R. Klaenhammer. 2005. Sequence analysis of the Lactobacillus plantarum bacteriophage phi JL-1. Gene 348:45-54.

Klaenhammer, T.R., A. Azcarate Peril, R. Barrangou, T. Doung and E. Altermann. 2005. Genomic perspectives on probiotic lactic acid bacteria. Bioscience Microflora 24:31-33.

Klaenhammer, T.R., R. Barrangou, B.L. Buck, M.A. Azcarate-Peril, E.Altermann. 2005. Genomic features of lactic acid bacteria effecting bioprocessing and health. FEMS Microbiology Reviews. 29:393-409.

McAuliffe, O., R. J. Cano, and T.R. Klaenhammer. 2005. Genetic analysis of two bile salt hydrolase activities in Lactobacillus acidophilus NCFM. Appl. Environ. Microbiol. 71:4925-4929.

Azcarate-Peril, M.A., O. McAuliffe, E. Altermann, S.Lick, W. M. Russell, and T.R. Klaenhammer. 2005. Microarray analysis of a two-component regulatory system involved in acid resistance and proteolytic activity in Lactobacillus acidophilus. Appl. Envir. Microbiol. 71:5794-5804.

Buck, B.L., E. Altermann, T. Svingerud, and T.R. Klaenhammer. 2005. Functional analysis of putative adhesion factors in Lactobacillus acidophilus NCFM. Appl. Environ.. Microbiol. 2005 71:8344-8351.

Altermann, E., and T.R. Klaenhammer. 2005. PathwayVoyager: pathway mapping using the Kyoto Encyclopedia of genes and genomes (KEGG) database. BMC Genomics 6:60.

Klaenhammer, T.R., W.M. deVos, and A. Mercenier. 2005. Genomics of probiotic lactic acid bacteria: impacts on functional foods. In Bioprocesses and biotechnology for functional foods and nutraceuticals. Marcel Dekker, NY, pp 63-78.

Duong, T., R. Barrangou, W.M. Russell, and T.R. Klaenhammer. 2005. Characterization of the tre Locus and Analysis of Trehalose Cryoprotection in Lactobacillus acidophilus NCFM. Appl. Environ. Microbiol. 72:1218-1225.

Klaenhammer, T.R., de Vos, W.M., and A. Mercenier. 2004. Genomics on probiotic bacteria: impacts on functional foods. In: Biotechnology for performance foods, functional foods & nutraceuticals. Neeser, J.R. and German, B. (eds): Marcel Dekker, Inc., NY. pp. 63-75.

Sturino, J.M. and T.R. Klaenhammer. 2004. Bacteriophage defense systems and strategies for lactic acid bacteria. Adv. Appl. Microbiol. 56:331-378.

Majhenic, A.C., K. Venema, G.E. Allison, B.B. Matijasic, I. Rogelj, and T.R. Klaenhammer. 2004. DNA analysis of the genes encoding acidocin LF221 A and acidocin LF221 B, two bacteriocins produced by Lactobacillus gasseri LF221. Appl. Microbiol. Biotechnol. 63:705-714.

Altermann, E., B.L. Buck, R. Cano, and T.R. Klaenhammer. 2004 Identification and phenotypic characterization of the cell-division protein CdpA. Gene 342:189-197.

Azcarate-Peril, M.A., E. Altermann, R.L. Hoover-Fitzula, R.J. Cano, and T.R. Klaenhammer. 2004. Identification and inactivation of genetic loci involved with Lactobacillus acidophilus acid tolerance. Appl. Environ.Microbiol. 70:5315-5322.

Sturino, J.M. and T.R. Klaenhammer. 2004. Antisense RNA targeting primase interferes with bacteriophage replication in Streptococcus thermophilus. Appl. Environ. Microbiol. 70:1735-1743.

Pridmore, R.D., B. Berger, F. Desiere D. Vilanova, C. Barretto, A.C. Pittet, M.C. Zwahlen, M. Rouvet, E. Altermann, R. Barrangou, B. Mollet, A. Mercenier, T.R. Klaenhammer, F. Arigoni, and M.A. Schell. 2004. The genome Sequence of the Probiotic Intestinal Bacterium Lactobacillus johnsonii NCC 533. Proc. Nat. Acad. Sci. U.S.A. 101:2512-2517.

Yildirim, S., W. Lin, A.D. Hitchins, L.A. Jaykus, E. Altermann, and T.R. Klaenhammer. 2004. Epidemic clone I-specific genetic markers in strains of Listeria monocytogenes serotype 4b from foods. Appl. Environ. Microbiol. 4158-4164.

Evans, M.A., B. Swaminathan, L. M. Graves, E. Altermann, T.R. Klaenhammer, R. C. Fink, S. Kernodle, and S. Kathariou. 2004. Genetic markers unique to Listeria monocytogenes serotype 4b differentiate epidemic clone II (hot dog outbreak strains) from other lineages. Appl. Environ. Microbiol. 70:2383-2390.

Ventura, M., C. Canchaya, V. Meylan, T.R. Klaenhammer, and R. Zink. 2003. Analysis, characterization, and loci of the tuf genes in Lactobacillus and Bifidobacterium species and their direct application for species evaluation. Appl. Environ. Microbiol. 69:6908-6922.

Andrus, J.M., S.W. Bowen, T.R. Klaenhammer, and H.M. Hassan. 2003. Molecular characterization and functional analysis of the maganese-containing superoxide dismutase gene (sodA) from Streptococcus thermophilus AO54. Arch. Biochem. Biophys. 420:103-113.

Altermann, E. and T.R. Klaenhammer. 2003. GAMOLA: a new local solution for sequence annotation and analyzing draft and finished prokayotic genomes. OMICS 7:161-169.

Reid, G., Sanders, M.E., Gaskins, H.R., Gibson, G.R., Mercenier, A., Rastall, R., Roberfroid, M., Rowland, I., Cherbut, C., and Klaenhammer, T.R. 2003. New scientific paradigms for probiotics and prebiotics. J. Clin. Gastroenterology 37:105-118.

Barrangou, R., E. Altermann, R. Hutkins, R. Cano, and T. Klaenhammer. 2003. Functional and comparative genomic analyses of an operon involved in fructooligosaccharide utilization by Lactobacillus acidophilus.
Proc. Nat. Acad. Sci. USA. 100:8957-8962.  Photo of the authors

Lu, J., F. Breidt, H.P. Fleming, E. Altermann, and T.R. Klaenhammer. 2003. Isolation and characterization of a Lactobacillus plantarum bacteriophage, phi JL-1, from a cucumber fermentation. International Journal of Food Microbiology, 84:225-235.

Roberts, R.J., M. Belfort, T. Bestor, A.S. Bhagwat, T.A. Bickle, J. Bitinaite, R.M. Blumenthal, S.K. Degtyarev, D.T.F. Dryden, K. Dybvig, K. Firman, E.S. Gromova, R.I. Gumport, S.E. Halford, S. Hattman, J. Heitman, D.P. Hornby, A. Janulaitis, A. Jeltsch, J. Josephsen, A. Kiss, T.R. Klaenhammer, I. Kobayashi, H. Kong, D.H. Krüger, S. Lacks, M.G. Marinus, M. Miyahara, R.D. Morgan, N.E. Murray, V. Nagaraja, A., A. Piekarowicz, A. Pingoud, E. Raleigh, D.N. Rao, N. Reich, V.E. Repin, E.U. Selker, P.-C. Shaw, D.C. Stein, B.L. Stoddard, W. Szybalski, T.A. Trautner, J.L. Van Etten, J.M.B. Victor, G.G. Wilson, and S.Y. Xu. 2003. A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes. Nucleic Acids Research 31:1805-1812.

Barrangou, R. S.K. Yoon, F. Breidt, H.P. Fleming, and T.R. Klaenhammer. 2002. Characterization of six Leuconostoc fallax bacteriophages isolated from an industrial sauerkraut fermentation. Appl. Environ. Microbiol. 68:5452-5458.

Durmaz, E., S.M. Madsen, H. Israelsen, and T.R. Klaenhammer. 2002. Lactococcus lactis lytic bacteriophages of the P335 group are inhibited by overexpression of a truncated CI repressor. J. Bacteriol. 184:6532-6543.

Barrangou, R. S.K. Yoon, F. Breidt, H.P. Fleming, and T.R. Klaenhammer. 2002. Identification and characterization of Leuconostoc fallax strains isolated from an industrial sauerkraut fermentation. Appl. Environ. Microbiol. 68:2877-2884.

Yother, J. P. Trieu Cuot, T.R. Klaenhammer, and W. M. de Vos. 2002. Genetics of Streptococci, Lactococci, and Enterococci: Review of the Sixth International Conference J. Bacteriol. 184:6085-6092.

Klaenhammer, T., E. Altermann, F. Arigoni, A. Bolotin, F. Breidt, J. Broadbent, R. Cano, S. Chaillou, J. Deutscher, M. Gasson, M. van de Guchte, J. Guzzo, A. Hartke, T. Hawkins, P. Hols, R. Hutkins, M. Kleerebezem, J. Kok, O. Kuipers, M. Lubbers, E. Maguin, L. McKay, D. Mills, A. Nauta, R. Overbeek, H. Pel, D. Pridmore, M. Saier, D. van Sinderen, A. Sorokin, J. Steele, D. O'Sullivan, W. de Vos, B. Weimer, M. Zagorec, and R. Siezen. 2002. Discovering lactic acid bacteria by genomics. Antonie van Leeuwenhoek 82:59-71.

McAuliffe, O., and T.R. Klaenhammer. 2002. Genomic perspectives on probiotics and the gastrointesinal microflora. In: Probiotics and Prebiotics: Where are we going? G. Tannock (ed.): Caister Academic Press, Norfolk, England. pp. 263-310.

Girgis, H.S., J. Smith, J.B. Luchansky, and T.R. Klaenhammer. 2002. Stress adaptations of lactic acid bacteria. In: Microbial adaptation to stress and safety of new-generation foods. Yousef, A.E. and Juneja, V.K. (eds.): CRC Press, NY. pp. 159-212.

Tuler, T.R., M.J.Callanan, and T.R. Klaenhammer. 2002. Overexpression of peptidases in Lactococcus and evaluation of their release from leaky cells. J. Dairy Sci. 85:2438-2450.

Yoon, S.S., R. Barrangou-Poueys, F.Breidt, T.R. Klaenhammer, and H.P. Fleming. 2002. Isolation and characterization of bacteriophages from fermenting sauerkraut. Appl. Environ. Microbiol. 68:973-976

Callanan, M.J. and T.R. Klaenhammer. 2002. Bacteriophages in industry. Encyclopedia of Life Sciences. Macmillan Publishers Ltd, Nature Publishing Group.

Sturino, J.M. and T. R. Klaenhammer. 2002. Expression of antisense RNA targeted against Streptococcus thermophilus bacteriophages . Appl. Environ. Microbiol. 68:588-596.

Russell, W.M. and T.R. Klaenhammer. 2001. An efficient system for directed integration into the Lactobacillus acidophilus and Lactobacillus gasseri chromosome via homologous recombination. Appl. Environ. Microbiol. 67:4361-4364.

Russell, W.M. and T.R. Klaenhammer. 2001. Identification and cloning of gusA, encoding a new B-glucuronidase from Lactobacillus gasseri ADH. Appl. Environ. Microbiol. 67:1253-1267.

Klaenhammer, T.R. 2001. Functional genomics and rational selection of probiotics. In: Montreal International Symposium Proceedings on Probiotics and Health:The Intestinal Microflora. pp. 1-7

Sanders, M.E. and T.R. Klaenhammer. 2001. The Scientific Basis of Lactobacillus acidophilus NCFM Functionality as a Probiotic. J. Dairy Sci. 84:319 331.

Klaenhammer, T.R. 2001. Probiotics and Prebiotics. In: Food Microbiology: Fundamentals and Frontiers. Doyle, M., Beauchat, L., and Montville, T. (eds.) ASM Press, Washington DC. Second Edition:Chapter 39 pp. 797-811.

Madsen, S.M., D. Mills, G.Djordjevic, H. Israelsen, and T.R. Klaenhammer. 2001. Analysis of the genetic switch and replication region of a P335-type bacteriophage with an obligate lytic lifestyle in Lactococcus lactis. Appl. Environ. Microbiol. 67:1128-1139.

Walker, S.A. and T.R. Klaenhammer. 2001. The genetics of phage resistance in Lactococcus lactis. In: The Lactic Acid Bacteria: The genetics of lactic acid bacteria. Wood, B.J.B and Warner, P. (eds.). Aspen Publishers, Volume 3:Chapter 10.

Walker, S.A. and T.R. Klaenhammer. 2001. Leaky Lactococcus cultures that externalize enzymes and antigens independently of culture lysis and secretion and export pathways. Appl. Environ. Microbiol. 67:251-259.

Kullen, M.J. and T.R. Klaenhammer. 2000. Genetic modification of intestinal lactobacilli and bifidobacteria. Curr. Issues Mol. Biol. 2:41-50.

Kullen, M.J., R.B. Sanozky-Dawes, D.C. Crowell, and T.R. Klaenhammer. 2000. Use of DNA sequence of variable regions of the 16SrRNA gene for rapid and accurate identification of bacteria in the Lactobacillus acidophilus complex. J. Appl. Microbiol. 89:511-518.

Durmaz, E. and T.R. Klaenhammer. 2000. Genetic analysis of chromosomal regions of Lactococcus lactis acquired by recombinant phages. Appl. Environ. Microbiol. 66:895-903.

Klaenhammer, T.R. and W.M. Russell. 2000. Species of the Lactobacillus acidophilus complex. Encyclopedia of Food Microbiology, Volume 2. Robinson, R.K, Batt, C., and Patel, P.D. (eds). Academic Press San Diego, pp. 1151-1157.

Walker, S.A. and T. R. Klaenhammer. 2000. An explosive antisense RNA strategy to prevent the proliferation of a lytic, lactococcal bacteriophage. Appl. Environ. Microbiol. 66:310 319.

Klaenhammer, T.R. 1999. Probiotic bacteria: today and tomorrow. J. Nutrition. 14:1S-2S.

Kullen, M.J. and T.R. Klaenhammer. 1999. Identification of the pH-inducible, proton-translocating F1F0-ATPase (atpBEFHAGDC) operon of Lactobacillus acidophilus by differential display: gene structure, cloning and characterization. Molecular Microbiology 33:1152-1161.

Girgis, H.S., D.C. Walker, and T.R. Klaenhammer. 1999. Correlation between groELS inducibility and protection from freeze injury in Lactobacillus acidophilus. In: Food Microbiology and Food Safety into the Next Millennium. Tuijtelaars, A.C.J., Samson, R.A., Rombouts, F.M., and Notermans, S. (eds.): Ponsen & Wooyen. Wageningen, The Netherlands, pp. 737-738.

Klaenhammer T.R. and M.J. Kullen. 1999. Selection and design of probiotics. International Journal of Food Microbiology 50:45-58.

Walker, D.C, H.S. Girgis, and T.R. Klaenhammer. 1999. The groELS chaperone operon of Lactobacillus johnsonii. Appl. Environ. Microbiol. 65:3033-3041

McCormick, J. K., T. R. Klaenhammer, and M. E. Stiles. 1999. Colicin V can be produced by lactic acid bacteria. Letters in Applied Microbiology 29:37 40.

Allison, G.E. and T.R. Klaenhammer. 1999. Genetics of bacteriocins produced by lactic acid bacteria and their use in novel industrial applications. pp. 789-808. In: Manual of Industrial Microbiology and Biotechnology. A.L. DeMain and J.E. Davies. (eds.): ASM Press, Washington, D.C.

Kullen, M.J. and T.R. Klaenhammer. 1999. Genetic modification of intestinal lactobacilli and bifidobacteria. In: Probiotics: a Critical Review. G. Tannock (ed.). Horizon Scientific Press, Wymondham, U.K. pp. 65-83.

Klaenhammer, T.R., J. F. Connelly. R. Fitzgerald, C. Stanton, and R.P.Ross. (eds.):1998. Special Issue: Functional Foods, Designer Foods for the Future. Int. Dairy Journal. Vol 5-6.

Allison, G.E. and T. R. Klaenhammer. 1998. Phage resistance mechanisms in lactic acid bacteria. Int. Dairy Journal. 8:207-226.

Djordjevic, G.M. and T.R. Klaenhammer. 1998. Genes and gene expression in Lactococcus bacteriophages. Int. Dairy Journal. 7:489-508.

O'Sullivan, D.J. and T.R. Klaenhammer. 1998. Control of expression of LlaI restriction in Lactococcus lactis. Mol. Microbiol. 27:1009-1020.

Walker, S.A., C.S. Dombroski, and T. R. Klaenhammer. 1998. Common elements regulating gene expression in temperate and lytic bacteriophages of Lactococcus species. Appl. Environ. Microbiol. 64:1147-1152.

Walker, S.A. and T.R. Klaenhammer. 1998. Molecular characterization of a phage-inducible middle promoter and its transcriptional activator from the lactococcal bacteriophage phi 31. J. Bacteriol. 180:921-931.

Djordjevic, G.M. and T.R. Klaenhammer. 1998. A method for mapping phage-inducible promoters for use in bacteriophage- triggered defense systems. Methods in Cell Science 20:119-126.

Klaenhammer, T.R. 1998. Functional activities of Lactobacillus probiotics: genetic mandate. Int. Dairy Journal. Int. Dairy. Journal. 8:497-506.

Djordjevic, G.M. and T.R. Klaenhammer. 1998. Inducible gene expression systems in Lactococcus lactis. Molecular Biotechnology 9:127-139.

Klaenhammer, T.R. 1997 Simposio Internacional De Bacterias Lacticas: CERELA XX. Novel approaches for the development of lactic acid bacteria resistant to phages. Aniverario. Technologia Lactea Latinoamericana No 7.

Klaenhammer, T.R. 1997. Probiotic roles of lactobacilli - genetic imperatives and opportunities. pp. 461-483, In: International Symposium on Lactic Acid Bacteria and Human Health 1979-1997. Korean Public Health Association, Seoul, Korea.

Djordjevic, G.M. and T.R. Klaenhammer. 1997. Bacteriophage-triggered defense systems: phage adaptation and design improvements. Appl. Environ. Microbiol. 63:4370-4376.

Dinsmore, P.K., D.J. O'Sullivan, and T.R. Klaenhammer. 1997. A leucine repeat motif in AbiA is required for resistance of Lactococcus lactis to phages representing three species. Gene. 212:5-11.

Djordjevic, G. M., D.J. O'Sullivan, S.A. Walker, M.A. Conkling, and T. R. Klaenhammer. 1997. Triggered-suicide system designed as a defense against bacteriophages. J. Bacteriol. 179:6741-6748.

Dinsmore, P.K. and T.R. Klaenhammer. 1997. Molecular characterization of a genomic region in a Lactococcus bacteriophage that is involved in its sensitivity to the phage defense mechanism AbiA. J. Bacteriol. 179:2949-2957.

Allison, G.E. and T. R. Klaenhammer. 1996. Functional analysis of the gene encoding immunity to lactacin F, lafI, and its use as a Lactobacillus-specific, food-grade genetic marker. Appl. Environ. Microbiol. 62, 4450-4460.

Sanders, M.E., D.C. Walker, K.M. Walker, K. Aoyama, and T.R. Klaenhammer. 1996. Performance of commercial cultures in fluid milk applications. J. Dairy Sci. 79:943-955.

Walker, D.C. , K. Aoyama, and T.R. Klaenhammer. 1996. Electrotransformation of Lactobacillus acidophilus group A1. FEMS Microbiol. Lett. 138:233-237.

Djordjevic, G.M. and T.R. Klaenhammer. 1996. Positive selection, cloning vectors for gram positive bacteria based on a restriction endonuclease cassette. Plasmid. 35:37-45.

O'Sullivan, D.J., S.A. Walker, S.G. West, and T.R. Klaenhammer. 1996. Development of an expression vector technology using a lytic phage to trigger explosive plasmid amplification and gene expression. Bio/Technology 14: 82-87.

Klaenhammer, T.R. 1995. Genetics of intestinal lactobacilli. Int. Dairy Journal 5:1019-1058.

Shefet, S.M., B.W. Sheldon, and T.R. Klaenhammer. 1995. Efficacy of optimized nisin-based treatments to inhibit Salmonella typhimurium and extend shelf-life of broiler carcasses. J. Food Prot. 58:1077-1082.

Allison, G.E., C. Ahn, M.E. Stiles, and T.R. Klaenhammer. 1995. Utilization of the leucocin A export system in Leuconostoc gelidum for production of a Lactobacillus bacteriocin. FEMS Microbiol. Lett. 131:87-93.

Abler, L.A., A.Klapes, B.W. Sheldon, and T. R. Klaenhammer. 1995. Inactivation of food-borne pathogens with magainin peptides. J. Food Protection 58:381-388.

Allison, G.E., R.W. Worobo, M.E. Stiles, and T. R. Klaenhammer. 1995. Heterologous expression of the lactacin F peptides by Carnobacterium pisicola LV17. Appl. Environ. Microbiol. 61:1371-1377.

Durmaz, E. and T.R. Klaenhammer. 1995. A starter culture rotation strategy incorporating paired restriction/modification and abortive infection bacteriophage defenses in a single Lactococcus lactis strain. Appl. Environ. Microbiol. 61:1266-1273.

Moineau, S., S. Pandian, and T.R. Klaenhammer. 1995. Specific chromosomal sequences can contribute to the appearance of a new lytic bacteriophage in Lactococcus. Genetics of the Streptococi, Enterococci, and Lactococci. Ferretti, J.J., Gilmore, M.S., Klaenhammer, T.R., and Brown, F. (eds): Dev. Biol. Stand. Basel, Karger. Vol. 85, pp. 577-580.

O'Sullivan, D.J. and T.R. Klaenhammer. 1995. CLlaI is a bifunctional regulatory protein of the llaI restriction modification operon from Lactococcus lactis. Genetics of the Streptococci, Enterococci, and Lactococci. Ferretti, J.J., Gilmore, M.S., Klaenhammer, T.R., and Brown, F. (eds): Dev. Biol. Stand. Basel, Karger. Vol. 85, pp. 591-595.

Dinsmore, P.K. and T.R. Klaenhammer. 1995. Bacteriophage resistance in Lactococcus. Molecular Biotechnology 4:297-314.

Klaenhammer, T.R., C. Fremaux, and Y. Hechard. 1994. Activity Antimicrobienne Des Bacteries Lactiques. In: Bacteries Lactiques. H de Rossart and F.M. Luquet (eds.): Lorica, Chemin de Saint Georges, France. Vol 1, Chapter I-11, pp. 353-366.

O'Sullivan, D.J., K. Zagula, and T.R. Klaenhammer. 1995. In vivo restriction by LlaI is encoded by three genes, arranged in a operon with llaIM, on the conjugative Lactococcus plasmid pTR2030. J. Bacteriol. 177:134-143.

Passos, F.M.L., T.R. Klaenhammer, and H.E. Swaisgood. 1994. Response to phage infection of immobilized lactococci during continuous acidification and inoculation of skim milk. J. Dairy Res. 61, 537-544.

Greene, J.D. and T.R. Klaenhammer. 1994. Factors involved in adherence of lactobacilli to human Caco-2 cells. Appl. Environ. Microbiol. 60:4487-4494.

Walker, D.C. and T.R. Klaenhammer. 1994. Isolation of a novel IS3 group insertion element and construction of an integration vector for Lactobacillus spp. J. Bacteriol. 176:5330-5340.

Moineau, S., S. Pandian, and T.R. Klaenhammer. 1994. Evolution of a lytic bacteriophage via DNA acquisition from the Lactococcus lactis chromosome. Appl. Environ. Microbiol. 60:1832-1841.

Abee, T., T.R. Klaenhammer, and L.Letellier. 1994. Kinetic studies on the action of lactacin F, a bacteriocin produced by Lactobacillus johnsonii that forms poration complexes in the cytoplasmic membrane. Appl. Environ. Microbiol. 60:1006-1013.

Allison, G.E., C. Fremaux, and T.R. Klaenhammer. 1994. Expansion of bacteriocin activity and host range upon complementation of two peptides encoded within the lactacin F operon. J. Bacteriol. 176:2235-2241.

Dinsmore, P.K., and T.R. Klaenhammer. 1994. Phenotypic consequences of altering the copy number of abiA, a gene responsible for aborting bacteriophage infections in Lactococcus lactis. Appl. Environ. Microbiol. 60:1129-1136.

Fremaux, C. and T.R. Klaenhammer. 1994. Helveticin J, a large heat-labile bacteriocin from Lactobacillus helveticus. In: Bacteriocins of Lactic Acid Bacteria: Microbiology, Genetics and Applications. De Vuyst, L. (ed.):Elsevier Applied Science Publishers, U.K. pp.397-418.

Klaenhammer, T.R., C. Ahn, and P. Muriana. 1994. Lactacin F, a small hydrophobic heat-stable bacteriocin from Lactobacillus johnsonii. In: Bacteriocins of Lactic Acid Bacteria: Microbiology, Genetics and Applications. De Vuyst, L. (ed.):Elsevier Applied Science Publishers, U.K. pp. 377-396.

Klaenhammer, T.R. and G.F. Fitzgerald. 1994. Bacteriophages and bacteriophage resistance. In: Genetics and Biotechnology of Lactic Acid Bacteria. M.J. Gasson and W. de Vos (eds.). Backie and Son, Ltd. U.K. pp. 106-168.

Dinsmore, P.K., D.A. Romero, and T.R. Klaenhammer. 1993. Insertional mutagenesis in Lactococcus lactis subsp. lactis mediated by IS946. FEMS Micrbiol. Letts. 107:43-48.

Klaenhammer, T.R., C. Fremaux, C. Ahn, and K. Milton. 1993. Molecular Biology of bacteriocins produced by Lactobacillus. In: Bacteriocins of Lactic Acid Bacteria. D.G. Hoover & L.R. Steenson (eds). Academic Press, Inc. NY, pp. 151-180.

Fremaux, C., C. Ahn, and T.R. Klaenhammer. 1993. Molecular analysis of the lactacin F operon. Appl. Environ. Microbiol. 59:3906-3915

Fremaux, C., G.L. DeAntoni, R.R. Raya, and T.R. Klaenhammer. 1993. Genetic organization and sequence of the region encoding integrative functions from Lactobacillus gasseri temperate bacteriophage Nadh. Gene 126:61-66

Polzin, K.M., D.A. Romero, M. Shimizu-Kadota, T.R. Klaenhammer, and L.L. McKay. 1993. Copy number and location of insertion sequences ISS1 and IS981 in lactococci and several other lactic acid bacteria. J. Dairy Sci. 76:1243-1252

O'Sullivan, D.J., C. Hill, and T.R. Klaenhammer. 1993. Effect of increasing copy number of bacteriophage origins of replication, in trans, on incoming phage proliferation. Appl. Environ. Microbiol. 59:2449-2456

O'Sullivan, D.J. and T.R. Klaenhammer. 1993. Rapid mini-prep isolation of high quality DNA from Lactococcus and Lactobacillus species. Appl. Environ. Microbiol. 59:2730-2733. Roy, D.G., T.R. Klaenhammer, and H.M. Hassan. 1993. Cloning and expression of the manganese superoxide dismutase gene of Escherichia coli in Lactococcus lactis and Lactobacillus gasseri. Mol. Gen. Genetics. 293:33-40

O'Sullivan, D.J. and T.R. Klaenhammer. 1993. High- and low-copy number Lactococcus shuttle cloning vectors with features for clone screening. Gene 137:227-231

Moineau, S., D. Bernier, M. Jobin, J. Hebert, T.R. Klaenhammer, and S. Pandian. 1993. Production of monoclonal antibodies against the major capsid protein of the Lactococcus bacteriophage ul36 and development of an enzyme-linked immunosorbent assay for direct phage detection in whey and milk. Appl. Environ. Microbiol. 59:2034-2040

Tannock, G.W., J.B. Luchansky, L. Miller, H. Connell, S. Thode-Andersen, A.A. Mercer, and T.R. Klaenhammer. 1994. Molecular characterization of a plasmid-borne (pGT633) erythromycin resistance determinant (ermGT) from Lactobacillus reuteri 100-63. Plasmid 31:60-71

Klaenhammer, T.R. 1993. Genetics of bacteriocins produced by lactic acid bacteria. FEMS Microbiol. Rev. 12:39-86. Romero, D.A. and T.R. Klaenhammer. 1993. Transposable elements in lactococci: a review. J. Dairy Sci. 76:1-19

Sing, W.D. and T.R. Klaenhammer. 1993. A strategy for rotation of different bacteriophage defenses in a lactococcal single-strain starter culture system. Appl. Environ. Microbiol. 59:365-372

Moineau, S., S. Pandian, and T.R. Klaenhammer. 1993. Restriction/modification systems and restriction endonucleases are more effective on lactococcal bacteriophages that have emerged recently in the dairy industry. Appl. Environ. Microbiol. 59:197-202

Moineau, S., E. Durmaz, S. Pandian, and T.R. Klaenhammer. 1993. Differentiation of two abortive mechanisms by using monoclonal antibiodies directed toward lactococcal bacteriophage capsid proteins. Appl. Environ. Microbiol. 59:208-212

O'Sullivan, D.J., K. Zagula, and T.R. Klaenhammer. 1993. Complete sequence and functional analysis of a plasmid encoded, multi-gene, restriction/modification operon from Lactococcus lactis subsp. lactis. Plasmid 30:181-182.

Stevens, K.A., B.W. Sheldon, N.A. Klapes, and T.R. Klaenhammer. 1992. Effect of treatment conditions on nisin inactivation of gram-negative bacteria. J. Food. Protection 55:763-766

Durmaz, E., D.L. Higgins, and T.R. Klaenhammer. 1992. Molecular characterization of a second abortive gene present in Lactococcus lactis subsp. lactis ME2. J. Bacteriol. 174:7463-7469

Raya, R.R., C. Fremaux, G.L. DeAntoni, and T.R. Klaenhammer. 1992. Site-specific integration of the temperate bacteriophage Nadh into the Lactobacillus gasseri chromosome and molecular characterization of the phage (attP) and bacterial (attB) attachment sites. J. Bacteriol. 174:5584-5592

Coconnier, M.H., T.R. Klaenhammer, S. Kerneis, M.-F. Bernet, and A.L. Servin. 1992. Protein-mediated adhesion of Lactobacillus acidophilus BG2FO4 on human enterocyte and mucus- secreting cell lines in culture. Appl. Environ. Microbiol. 58:2034-2039

Harris, L.J., H.P. Fleming, and T.R. Klaenhammer. 1992. Developments in nisin research. Food Res. Intl. 25:57-66

Klaenhammer, T.R., C. Ahn, C. Fremaux, and K. Milton. 1992. Molecular properties of Lactobacillus bacteriocins. In: Bacteriocins, microcins and lantibiotics. R. James, C. Lazdunski, and F. Pattus (eds.). Springer-Verlag, Berlin, Vol. H65, pp. 37-58.

Harris, L.J., H.P. Fleming, and T.R. Klaenhammer. 1992. Characterization of two nisin-producing Lactococcus lactis subsp. lactis strains isolated from a commercial sauerkraut fermentation. Appl. Environ. Microbiol. 58:1477-1483.

Harris, L.J., H.P. Fleming, and T.R. Klaenhammer. 1992. Novel paired starter culture system for sauerkraut, consisting of a nisin-resistant Leuconostoc mesenteroides strain and a nisin-producing Lactococcus lactis strain. Appl. Environ. Microbiol. 58:1484-1489.

Stevens, K.A., N.A. Klapes, B.W. Sheldon, and T.R. Klaenhammer. 1992. Antimicrobial action of nisin against Salmonella typhimurium lipopolysaccharide mutants. Appl. Environ. Microbiol. 58:1786-1788

Klaenhammer, T.R. 1992. Genetic strategies to develop bacteriophage-insensitive lactic acid bacteria for industrial fermentations. Proceedings from the Tenth Australian Biotechnology Conference, Australian Biotechnology Association Ltd, Melbourne.

Foegeding, P.M., A.B. Thomas, D.H. Pilkington, and T.R. Klaenhammer. 1992. Enhanced control of Listeria monocytogenes by in situ-produced pediocin during dry fermented sausage production. Appl. Environ. Microbiol. 58:884-890

Klaenhammer, T.R., C. Fremaux, C. Ahn, and K. Milton. 1992. Molecular Biology of bacteriocins produced by Lactobacillus. In: Bacteriocins and Lactic Acid Bacteria. D. Hoover & L. Steenson (eds), Academic Press, NY, pp 151-180

Piard, J.C., P.M. Muriana, M.J. Desmazeaud, and T.R. Klaenhammer. 1992. Purification and partial characterization of lacticin 481, a lanthionine-containing bacteriocin produced by Lactococcus lactis CNRZ 481. Appl. Environ. Microbiol. 58:279-284

Stevens, K.A., B.W. Sheldon, N.A. Klapes, and T.R. Klaenhammer. 1992. Nisin treatment for inactivation of Salmonella species and other gram-negative bacteria. Appl. Environ. Microbiol. 57:3613-3615.

Romero, D.A. and T.R. Klaenhammer. 1992. IS946-mediated integration of heterologous DNA into the genome of Lactococcus lactis subsp. lactis. Appl. Environ. Microbiol. 58:699-702.

Raya, R.R. and T.R. Klaenhammer. 1992. High frequency transduction by the Lactobacillus gasseri bacteriophage Nadh. Appl. Environ. Microbiol. 58:187-193.

Romero, D.A. and T.R. Klaenhammer. 1991. Construction of an IS946-based composite transposon in Lactococcus lactis subsp. lactis. J. Bacteriol. 173:7599-7606.

Luchansky, J.B., M.C. Tennant, and T.R. Klaenhammer. 1991. Molecular cloning and DNA polymorphisms in Lactobacillus acidophilus and Lactobacillus gasseri. J. Dairy Sci. 74:3293-3302.

Klaenhammer, T.R., D. Romero, W. Sing, and C. Hill. 1991. Molecular analysis of pTR2030 gene systems that confer phage resistance to lactococci. In: Genetics and Molecular Biology of Streptococci, Lactococci, and Enterococci. G. Dunny, P. Cleary, and L. McKay (eds): American Society for Microbiology, Washington DC. pp. 124-130.

Klaenhammer, T.R. 1991. Development of bacteriophage resistant strains of lactic acid bacteria. Biochemical Society Transactions 19:675-681.

Klaenhammer, T.R. 1991. Antimicrobial and bacteriocin interactions of the lactic acid bacteria. Proceedings of the Sixth International Symposium on Genetics of Industrial Microorganisms, Vol. I:433-445.

Harris, L.J., H.P. Fleming, and T.R. Klaenhammer. 1991. Sensitivity and resistance of Listeria monocytogenes ATCC 19115, Scott A, and UAL500 to nisin. J. Food Protection 54:836-840.

Hill, C., L.M. Miller, and T.R. Klaenhammer. 1991. In vivo genetic exchange of a function domain from a type II-A-methylase between the lactococcal plasmid pTR2030 and a virulent bacteriophage. J. Bacteriol. 173:4363-4370.

Alatossava, T. and T.R. Klaenhammer. 1991. Molecular characterization of three small isometric-headed bacteriophages which vary in their sensitivity to the lactococcal phage resistance plasmid, pTR2030. Appl. Environ. Microbiol. 57:1346-1353.

Muriana, P.M. and T.R. Klaenhammer. 1991. Purification and partial characterization of lactacin F, a bacteriocin produced by Lactobacillus acidophilus 11088. Appl. Environ. Microbiol. 57:114-121.

Muriana, P.M. and T.R. Klaenhammer. 1991. Cloning, phenotypic expression, and DNA sequence of the gene for lactacin F, an antimicrobial peptide produced by Lactobacillus spp. J. Bacteriol. 173:1779-1788.

Hill, C., I.J. Massey, and T.R. Klaenhammer. 1991. A rapid method to characterize lactococcal bacteriophage genomes. Appl. Environ. Microbiol. 57:283-288.

Hill, C., L.A. Miller, and T.R. Klaenhammer. 1991. The bacteriophage resistance plasmid pTR2030 forms high molecular weight multimers in lactococci. Plasmid 25:105-112

Sing, W.D. and T.R. Klaenhammer. 1991. Characterization of restriction and modification plasmids from Lactococus lactis subsp. cremoris and their effects when combined with pTR2030. J. Dairy Sci. 74:1133-1144.

Hill, C., L.A. Miller, and T.R. Klaenhammer. 1990. Cloning, expression, and sequence determination of bacteriophage fragment encoding bacteriophage resistance in Lactococcus lactis. J. Bacteriol. 172:6419-6426.

Romero, D.A. and T.R. Klaenhammer. 1990. Characterization of insertion sequence IS946, and iso-ISS1 element, isolated from the conjugative lactococcal plasmid pTR2030. J. Bacteriol. 172:4151-4160.

Joerger, M.C. and T.R. Klaenhammer. 1990. Cloning, expression, and nucleotide sequence of the Lactobacillus helveticus 481 gene encoding the bacteriocin helveticin J. J. Bacteriol. 172:6339-6347.

Romero, D.R. and T.R. Klaenhammer. 1990. Abortive phage infection and restriction/modification activities directed by pTR2030-determinants are enhanced by recombination with conjugal plasmids in lactococci. J. Gen. Microbiol. 136:1817-1824

Hill, C., L.A. Miller, and T.R. Klaenhammer. 1990. Nucleotide sequence and distribution of the pTR2030 resistance determinant (hsp) which aborts bacteriophage infection in lactococci. Appl Environ. Microbiol. 56:2255-2258.

Sing, W.D. and T.R. Klaenhammer. 1990. Characterization of phage abortion conferred in lactococci by the conjugal plasmid pTR2030. J. Gen. Microbiol. 136:1807-1815

Josephsen, J. and T.R. Klaenhammer. 1990. Stacking of three different restriction and modification systems in Lactococcus lactis by cotransformation. Plasmid 23:71-75.

Sing, W.D. and T.R. Klaenhammer. 1990. Plasmid-induced abortive infection in lactococci: A review. J. Dairy Sci. 73:2239-2251

Klaenhammer, T.R. 1989. Genetic characterization of multiple mechanisms of phage defense from a prototype phage-insensitive strain, Lactococcus lactis ME2. J. Dairy Sci. 72:3429-3443.

Hill, C., K. Pierce, and T.R. Klaenhammer. 1989. The conjugative plasmid pTR2030 encodes two bacteriophage defense mechanisms in lactococci, restriction modification (R+/M+) and abortive infection (Hsp+). Appl. Environ. Microbiol. 55:2416-2419

Raya, R.R., E.G. Kleeman, J.B. Luchansky, and T.R. Klaenhammer. 1989. Characterization of the temperate bacteriophage adh and plasmid transduction in Lactobacillus acidophilus ADH. Appl. Environ. Microbiol. 55:2206-2213

Harris, L.J., M.A. Daeschel, M.E. Stiles, and T.R. Klaenhammer. 1989. Antimicrobial activity of lactic acid bacteria against Listeria monocytogenes. J. Food Protect. 52:384-387

Luchansky, J.B., E.G. Kleeman, R.R. Raya, and T.R. Klaenhammer. 1989. Genetic transfer systems for delivery of plasmid deoxyribonucleic acid to Lactobacillus acidophilus ADH: conjugation, electroporation, and transduction. J. Dairy Sci. 72:1408-1417

Hill, C., D.A. Romero, D.S. McKenney, K.R. Finer, and T.R. Klaenhammer. 1989. Localization, cloning, and expression of genetic determinants for bacteriophage resistance (Hsp) from the conjugative plasmid pTR2030. Appl. Environ. Microbiol. 55:1684-1689

Luchansky, J.B., P.M. Muriana, and T.R. Klaenhammer. 1988. Application of electroporation for transfer of plasmid DNA to Lactobacillus, Lactococcus, Leuconostoc, Listeria, Pediococcus, Bacillus, Staphylococcus, Enterococcus, and Propionibacterium. Mol. Microbiol. 2:637-647

Higgins, D.L., R.B. Sanozky-Dawes, and T.R. Klaenhammer. 1988. Restriction and modification activities from Streptococcus lactis ME2 are encoded by a self-transmissible plasmid, pTN20, that forms cointegrates during mobilization of lactose-fermenting ability. J. Bacteriol. 170:3435-3442

Klaenhammer, T.R. 1988. Bacteriocins of lactic acid bacteria. Biochimie. 70:337-349

Klaenhammer, T.R. 1987. Plasmid-directed mechanisms for bacteriophage defense in lactic streptococci. FEMS Microbiol. Rev. 46:313-325

Steenson, L.R., T.R. Klaenhammer, and H.E. Swaisgood. 1987. Calcium alginate-immobilized cultures of lactic streptococci are protected from attack by lytic bacteriophage. J. Dairy Sci. 70:1121-1127

Muriana, P.M. and T.R. Klaenhammer. 1987. Conjugal transfer of plasmid-encoded determinants for bacteriocin production and immunity in Lactobacillus acidophilus 88. Appl. Environ. Microbiol. 53:553-560.

Steenson, L.R. and T.R. Klaenhammer. 1987. Conjugal transfer of plasmid DNA between streptococci immobilized in calcium alginate gel beads. Appl.Environ. Microbiol. 53:898-900.

Jarvis, A.W. and T.R. Klaenhammer. 1987. The phage resistance plasmid pTR2030 inhibits lytic infection of R1T temperate phage, but not induction of R1T prophage in Streptococcus cremoris R1. Appl. Environ. Microbiol. 53:385-389.

Steenson, L.R. and T.R. Klaenhammer. 1986. Plasmid heterogeneity in Streptococcus cremoris M12R: effects on proteolytic activity and host-dependent phage replication. J. Dairy Sci. 69:2227-2236.

Sanders, M.E., P.J. Leonhard, W.D. Sing, and T.R. Klaenhammer. 1986. Conjugal strategy for construction of fast-acid producing, bacteriophage resistant lactic streptococci for use in dairy fermentations. Appl. Environ. Microbiol. 52:1001-1007.

Joerger, M.C. and T.R. Klaenhammer. 1986. Characterization and purification of helveticin J: evidence for a chromosomally determined bacteriocin produced by Lactobacillus helveticus-jugurt 481. J. Bacteriol. 167:439-446.

Jarvis, A.W. and T.R. Klaenhammer. 1986. Phage resistance conferred on lactic streptococci by the conjugative plasmid pTR2030: effects on small isometric, large isometric, and prolate headed phages. Appl. Environ. Microbiol. 51:1272-1277.

Sing, W.D. and T.R. Klaenhammer. 1986. Conjugal transfer of bacteriophage resistance determinants on pTR2030 into Streptococcus cremoris strains. Appl. Environ. Microbiol. 51:1264-1271.

Daeschel, M.A. and T.R. Klaenhammer. 1985. Association of a 13.6 megadalton plasmid in Pediococcus pentosaceus with bacteriocin activity. Appl. Environ. Microbiol. 50:1538-1541.

Steenson, L.R. and T.R. Klaenhammer. 1985. Streptococcus cremoris M12R transconjugants carrying the conjugal plasmid pTR2030 are insensitive to attack by lytic bacteriophages. Appl. Environ. Microbiol. 50:851-858.

Klaenhammer, T.R. and R.B. Sanozky. 1985. Conjugal transfer from Streptococcus lactis ME2 of plasmids encoding phage resistance, nisin resistance, and lactose fermenting ability: evidence for a high frequency conjugative plasmid responsible for abortive infection of virulent bacteriophage. J. Gen. Microbiol. 131:1531-1541.

Barefoot, S.F. and T.R. Klaenhammer. 1984. Purification and characterization of theLactobacillus acidophilus bacteriocin lactacin B. Antimicrobial Agents Chemother. 26:328-334.

Sanders, M.E. and T.R. Klaenhammer. 1984. Phage resistance in a phage-insensitive strain of Streptococcus lactis: temperature dependent phage development and host-controlled phage replication. Appl. Environ. Microbiol. 47:979-985.

Klaenhammer, T.R. 1984. Interactions of bacteriophages with lactic streptococci. Advances in Applied Microbiology. Allen I. Laskin (ed.):Academic Press New York, Volume 30 pp. 1-29.

Klaenhammer, T.R. 1984. A general method for plasmid isolation in lactobacilli. Current Microbiology 10:23-28.

Daeschel, M.A., R.F. McFeeters, H.P. Fleming, T.R. Klaenhammer, and R.B. Sanozky. 1984. Mutation and selection of Lactobacillus plantarum strains that do not produce carbon dioxide from malate. Appl. Environ. Microbiol. 47:419-420.

Wright, C.T. and T.R. Klaenhammer. 1984. Use of phosphated milk adversely affects the growth, cellular morphology and fermentative ability of Lactobacillus bulgaricus. J. Dairy Sci. 67:44-51.

Sanders, M.E. and T.R. Klaenhammer. 1983. Characterization of phage-sensitive mutants from a phage insensitive strain of Streptococcus lactis: evidence for a plasmid determinant that prevents phage adsorption. Appl. Environ. Microbiol. 46:1125-1133.

Wright, C.T. and T.R. Klaenhammer. 1983. Influence of calcium and manganese on dechaining of Lactobacillus bulgaricus. Appl. Environ. Microbiol. 46:785-792.

Wright, C.T. and T.R. Klaenhammer. 1983. Survival of Lactobacillus bulgaricus during freezing and freeze drying after growth in the presence of calcium. J. Food Sci. 48:773-777.

Barefoot, S.F. and T.R. Klaenhammer. 1983. Detection and activity of lactacin B, a bacteriocin produced by Lactobacillus acidophilus. Appl. Environ. Microbiol. 45:1808-1815.

Kleeman, E.G. and T.R. Klaenhammer. 1982. Adherence of Lactobacillus species to human fetal intestinal cells. J. Dairy Sci. 65:2063-2069.

Klaenhammer, T.R. 1982. Microbiological considerations in the selection and preparation of Lactobacillus strains for use as dietary adjuncts. J. Dairy Sci. 65:1339-1349.

Wright, C.T. and T.R. Klaenhammer. 1981. Calcium induced alteration of cellular morphology affecting the resistance of Lactobacillus acidophilus to freezing. Appl Environ. Microbiol. 41:807-815.

Sanders, M.E. and T.R. Klaenhammer. 1981. Evidence for plasmid linkage of restriction and modification in Streptococcus cremoris KH. Appl. Environ. Microbiol. 42:944-950.

Klaenhammer, T.R. and E.G. Kleeman. 1981. Growth characteristics, bile sensitivity, and freeze damage in colonial variants of Lactobacillus acidophilus. Appl. Environ. Microbiol. 41:1461-1467.

Sanders, M.E. and T.R. Klaenhammer. 1980. Restriction and modification in the group N streptococci: the effect of heat on the development of modified lytic bacteriophage. Appl. Environ. Microbiol. 40:500-506.

Klaenhammer, T.R. and S.M. Sutherland. 1980. Detection of plasmid DNA in an isolate of Lactobacillus acidophilus. Appl. Environ. Microbiol. 39:671-674.

Klaenhammer, T.R., L.L. McKay, and K.A. Baldwin. 1978. Improved lysis of group N streptococci for isolation and rapid characterization of plasmid deoxyribonucleic acid. Appl. Environ. Microbiol. 35:592-600.

Klaenhammer, T.R. and L.L. McKay. 1976. Isolation and examination of transducing bacteriophage particles from Streptococcus lactis C2. J. Dairy Sci. 59:396-404.

updated January 2010

< Home